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After an experimental bio-nerve gas is accidentally released at a remote U.S. military base in Texas, those exposed to the gas turn into flesh-eating, mutating zombies out to kill. An assortment of various people who include stripper Cherry, her shady mechanic ex-boyfriend Wray, a strong-willed doctor, the local sheriff, and an assortment of various people must join forces to survive the night as the so-called “sickos” threaten to take over the whole town and the world.

Jared Cole and his girlfriend Sam Nicholson are a young couple living in the Caribbean. Jared is an unemployed diver whose dream is to find treasure in the Caribbean Sea and Sam works at a local resort as a shark handler. When Jared’s best friend Bryce Dunn, a selfish New York lawyer and his new girlfriend Amanda Collins arrive, the two couples spend a couple of days experiencing paradise. But, they discover an airplane on the sea floor that crashed during a hurricane and they find the cargo on-board the airplane is cocaine. Jared and Sam’s lives are in danger, when Bryce and Amanda make a deal with a dangerous drug lord who wants the cocaine. Jared’s rival, Treasure Hunter Derek Bates learns what they are doing and tries to negotiate the cocaine to raise money for a expedition where he intends to find a sunken boat with treasure. Jared, Sam, Bryce, and Amanda find themselves racing against time to find the shipwreck before somebody else does.

Elisabeth Shue is Linda Foster, a scientist who is working on a serum to make people invisible. When another scientist tries the serum and becomes invisible his colleagues figure another way to bring him back to the normal world.